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Moving with Motegrity

From CIC relief to possible side effects and dosing, here's what to expect with Motegrity, an FDA-approved prescription medicine for adults with Chronic Idiopathic Constipation (CIC).

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CIC Relief

The ability of Motegrity to relieve the infrequency of bowel movements was studied in six clinical trials with 2,484 adults living with Chronic Idiopathic Constipation (CIC). About 3 in 4 were women, with an average age of 47 (ranging from 17 to 95). Many had been living with symptoms of CIC for years. While your results may vary, here's how Motegrity was shown to help:

Select Important Safety Information

Do not take Motegrity if you:

  • are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
  • have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn's disease, ulcerative colitis.

It's about having ‘complete’ trips more often

If you've lived with CIC, you may know how difficult getting that “complete” feeling can be when it comes to your bowel movements (BMs). During 12-week studies, Motegrity was shown to help normalize the number of complete BMs per week for adults living with CIC (and by normalize, we mean at least 3 complete BMs per week on average).

Relief held steady through 12-week studies

Motegrity improved the number of complete spontaneous bowel movements (CSBMs) per week as early as week 1. And what's more? This improvement was maintained through week 12 (which was the length of the studies).

And if you're tired of waiting:

People who started Motegrity had their first CSBM from 7 to 15 days sooner, on average, than those taking a placebo — a pill with no active ingredient (ranged from 1.4 to 4.7 days compared with 9.1 to 20.6 days).

Possible Side Effects

The safety profile of Motegrity was studied in six clinical trials involving more than 2,500 adults with CIC, about half of whom received Motegrity. Motegrity may cause serious side effects, including: unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your healthcare provider immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.

The most common side effects of Motegrity include: headache, stomach area (abdominal) pain or bloating, nausea, diarrhea, dizziness, vomiting, gas and fatigue. If reported, diarrhea or headache typically occurred within the first week of treatment and resolved within a few days of continued use.

These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects.

Your doctor can tell you more about Motegrity. Not sure how to ask?

Once-Daily Dosing

Busy schedule?

There's no need to complicate things with Motegrity. Just one tablet a day. Anytime. With or without food. And of course, always follow your doctor's specific instructions — if you have kidney problems, your doctor may give you a lower dose of Motegrity.

1 tablet a day

With or without food

Staying on track!

Motegrity was shown to be effective when taken once daily, so it's very important to take it every day as prescribed — not just on days when you are experiencing symptoms.

Store your Motegrity properly

  • Motegrity should stay in its original container (it protects from moisture)
  • Store the container at room temperature (68°F to 77°F)
  • Keep Motegrity and all medicines out of the reach of children
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Select Important Safety Information

Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:

  • have or have had depression, suicidal thoughts or actions, or mood problems
  • have kidney problems. Your HCP may give you a lower dose of Motegrity
  • are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby
  • are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Frequently Answered Questions

  • To learn more about CIC, including its symptons and associated risk factors, click here.

  • If you're unsure about how to approach your doctor about CIC, use this handy tool to help guide you through the conversation.

  • Motegrity targets a receptor in your colon involved in natural movements of the colon muscle (known as peristalsis). You can learn more about how Motegrity works by clicking here.

  • While your results may vary, people who started Motegrity in clinical studies had their first complete bowel movement within 1.4 to 4.7 days, compared with 9.1 to 20.6 days for people taking placebo. Learn more about the results and what to expect here.

  • While everyone’s body is different, the effect of Motegrity on improved bowel movement frequency was maintained through the 12-week clinical studies. Learn more about the results and what to expect here.

  • One tablet of Motegrity should be taken once a day, anytime, with or without food (or exactly as directed by your doctor). It may help to follow a routine like “after breakfast” or “before bed” so you don’t forget. See more dosing information here.

  • Motegrity may cause serious side effects, including unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your healthcare provider immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.

    Common side effects of Motegrity include headache, stomach area (abdominal) pain or bloating, nausea, diarrhea, dizziness, vomiting, gas and fatigue. These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects. Learn more about side effects and what to expect here.

  • Do not take Motegrity if you are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat. You should also not take Motegrity if you have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease or ulcerative colitis.

  • Sure are! Eligible patients may pay as little as $15 per 30-day prescription or $45 per 90-day prescription of Motegrity.* Learn more about Motegrity savings offer here.

    *Up to $90 max benefit per 30-day prescription; $270 max benefit per 90-day prescription. Terms and conditions apply. See link above for details.

  • Takeda offers support to patients that need help paying for Motegrity through the Help At Hand program. Click the link to learn more and to find out if you are eligible.

WHAT IS MOTEGRITY?

Motegrity is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). Idiopathic means the cause of the constipation is unknown. It is not known if Motegrity is safe and effective in children.

Important Safety Information

Do not take Motegrity if you:

  • are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
  • have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease, ulcerative colitis.

Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:

  • have or have had depression, suicidal thoughts or actions, or mood problems
  • have kidney problems. Your HCP may give you a lower dose of Motegrity
  • are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby
  • are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Motegrity?
Motegrity may cause serious side effects, including:

  • unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your HCP immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.
The most common side effects of Motegrity include:
  • headache
  • stomach area (abdominal) pain or bloating
  • nausea
  • diarrhea
  • dizziness
  • vomiting
  • gas
  • fatigue

These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. 
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for full Prescribing Information and Patient Information.

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