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The Basics of CIC

Interested in learning more about Chronic Idiopathic Constipation (CIC)? You've come to the right place!

Scroll down to learn more!

So what exactly is CIC?

Chronic Idiopathic Constipation (CIC) is a condition that affects bowel function, where “chronic” means having symptoms for at least 6 months, while “idiopathic” means that the specific cause isn’t known. Patients with CIC in the Motegrity clinical studies may have experienced the following symptoms:

  • Infrequent and/or incomplete bowel movements
  • Straining at defecation
  • Hard stools

If these symptoms sound familiar to you, you're not alone. Speak to your doctor about CIC.

Don't worry... you're not alone!

An estimated 46 million adults in the US may be affected by CIC.* So don't be afraid to speak up to find the relief you're looking for.

*Based on global prevalence of 14%. Treatment may not be appropriate for everyone who has CIC.

What are the
risk factors of CIC?

In other words, is CIC more likely to affect some than others? Here are a few of the possible risk factors that may contribute to developing CIC:

Gender

Women are more at-risk than men

Age

The risk of CIC increases as you age

Diet

Low-calorie diets may increase risk

Sedentary Lifestyle

Lack of physical activity and exercise may also increase risk

Low Fiber & Water Intake

Not consuming enough of either may lead to developing CIC

Other Medications

Those taking certain medications may be at an increased risk

Keep in mind

Although there are several risk factors associated with CIC, you may still develop this condition even if these risk factors do not apply to you.

What are some ways to better manage CIC?

Don't let CIC get the best of you. If you're having a hard time dealing with your condition, here are some tips and tricks that may help to better manage your symptoms.

Fiber Intake

Gradually increase the amount of fiber you consume to 20 to 30 g per day

Water Intake

Ensure you're hydrating enough every day

Exercise

Try to incorporate regular exercise into your daily routine

Stress Levels

Do what you can to reduce the amount of stress in your life

Keep in mind

If you’ve already tried making these changes to your lifestyle, and you still aren’t finding the relief you’re looking for, it may be time to speak with your doctor about Motegrity.

Not sure how? Here's a useful tool to help guide you through the discussion.

WHAT IS MOTEGRITY?

Motegrity is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). Idiopathic means the cause of the constipation is unknown. It is not known if Motegrity is safe and effective in children.

Important Safety Information

Do not take Motegrity if you:

  • are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
  • have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease, ulcerative colitis.

Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:

  • have or have had depression, suicidal thoughts or actions, or mood problems
  • have kidney problems. Your HCP may give you a lower dose of Motegrity
  • are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby
  • are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Motegrity?
Motegrity may cause serious side effects, including:

  • unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your HCP immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.
The most common side effects of Motegrity include:
  • headache
  • stomach area (abdominal) pain or bloating
  • nausea
  • diarrhea
  • dizziness
  • vomiting
  • gas
  • fatigue

These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. 
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for full Prescribing Information and Patient Information.

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