Actor Portrayal

Made to move your
colon muscle

Motegrity is the only prescription medicine of its kind for adults with Chronic Idiopathic Constipation (CIC). Scroll to learn more about how it moves your colon muscle.

Chronic means having symptoms
for at least 6 months.
Idiopathic means the cause of the constipation is unknown.

Moves by
Motegrity

When you think Motegrity,
think colon muscle movement

Unlike other prescription medications for Chronic Idiopathic Constipation (CIC), Motegrity works differently by enhancing natural movements of the colon muscle, known as peristalsis.

Select Important Safety Information

Do not take Motegrity if you:

  • are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
  • have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn's disease, ulcerative colitis.

Here's how Motegrity works in 3 steps:

Ready. Set. Move.

Number 1 Number 1
Ready

Taking Motegrity releases

the active ingredient

It's absorbed and
gets to work

Number 2 Number 2
Set

It targets a specific
receptor* in your colon

This enhances natural
movements of the
colon muscle

*Receptors are molecules that help
cells
communicate and bring about
responses,
such as colon muscle
movements.

Number 3 Number 3
Move

Rhythmic muscle
movements
in your
colon are increased

This helps your
bowels move

You should know!

Motegrity is a “prokinetic” medicine
because it promotes colonic movement

Select Important Safety Information

Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:

  • have or have had depression, suicidal thoughts or actions, or mood problems
  • have kidney problems. Your HCP may give you a lower dose
  • are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby
  • are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Why My
Colon Muscle?

Colon muscle movement Colon muscle movement

CIC and the moves behind bowel movements

As you can imagine, the muscle in our colon plays an important role in healthy bowel movements. So what about CIC? While the exact cause isn't known, it's thought that CIC may be caused by insufficient movement of the colon muscle.

Is Motegrity right for me?

Ask your doctor

About
Chronic Idiopathic
Constipation

Gender

Women are more at-risk than men

Age

The risk of CIC increases as we age

Diet

Low-calorie diets
may increase risk

CIC symptoms and
possible risk factors

Chronic Idiopathic Constipation, or CIC for short, is a chronic bowel condition affecting as many as 35 million adults in the United States.* Chronic means having symptoms for at least 6 months. The term “idiopathic” simply means that the specific cause isn't known.

If you have CIC, you probably know the symptoms all too well. People entering Motegrity studies were living with infrequent and incomplete bowel movements, and may have experienced straining and hard stools.

Sound familiar?

You shouldn't have to manage symptoms of CIC alone. Be open when discussing them with your doctor and find out if Motegrity can help. And remember — just because CIC is “idiopathic”, it doesn't mean that effective treatments aren't available.

*Treatment may not be appropriate for everyone who has CIC.

What is Motegrity?

Motegrity is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). Idiopathic means the cause of the constipation is unknown. It is not known if Motegrity is safe and effective in children.

Important Safety Information

Do not take Motegrity if you:

  • are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
  • have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease, ulcerative colitis.

Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:

  • have or have had depression, suicidal thoughts or actions, or mood problems
  • have kidney problems. Your HCP may give you a lower dose
  • are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby
  • are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Motegrity?
Motegrity may cause serious side effects, including:

  • unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your HCP immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or have tried to hurt yourself.

The most common side effects of Motegrity include:

  • headache
  • stomach area (abdominal) pain or bloating
  • nausea
  • diarrhea
  • dizziness
  • vomiting
  • gas
  • fatigue

These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for full Prescribing Information and Patient Information.