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Actor Portrayal

Made to move your colon muscle

Motegrity is the only prescription medicine of its kind for adults with Chronic Idiopathic Constipation (CIC). Scroll to learn more about how it moves your colon muscle.

Chronic means having symptoms for at least 6 months. Idiopathic means the cause of the constipation is unknown.

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Why My Colon Muscle?

Colon muscle movement

Why My
Colon Muscle?

CIC and the moves behind bowel movements

As you can imagine, the muscle in our colon plays an important role in healthy bowel movements. So what about Chronic Idiopathic Constipation (CIC)? While the exact cause isn't known, it's thought that CIC may be caused by insufficient movement of the colon muscle.

Colon muscle movement
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Moves by Motegrity

When you think Motegrity, think colon muscle movement

Unlike other prescription medications for Chronic Idiopathic Constipation, Motegrity works differently by stimulating natural movements of the colon muscle, known as peristalsis.

Here's how Motegrity works in 3 steps:

Ready. Set. Move.

Ready

Taking Motegrity releases the active ingredient

It's absorbed and gets to work

Set

It targets a specific
receptor* in your colon

This stimulates natural movements of the colon muscle

*Receptors are molecules that help cells communicate and bring about responses, such as colon muscle movements.

Move

Rhythmic muscle movements in your colon are increased

This helps your bowels move

You should know!

Motegrity is a "prokinetic" medicine because it promotes colonic movement.

Motegrity helps move your colon muscle, but don't just take it from us!

Hear real patients talk about their real experiences, and ask your doctor if Motegrity is right for you.

IMPORTANT SAFETY
INFORMATION ABOUT MOTEGRITY

Expand Collapse

Please expand for Indication and Important Safety Information.

Do not take Motegrity if you:

  • are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
  • have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease, ulcerative colitis.

Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:

  • have or have had depression, suicidal thoughts or actions, or mood problems.
  • have kidney problems. Your HCP may give you a lower dose of Motegrity.
  • are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Motegrity?
Motegrity may cause serious side effects, including:

  • unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your HCP immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.
The most common side effects of Motegrity include:
  • headache
  • stomach area (abdominal) pain or bloating
  • nausea
  • diarrhea
  • dizziness
  • vomiting
  • gas
  • fatigue

These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. 
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

WHAT IS MOTEGRITY?

Motegrity is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). Idiopathic means the cause of the constipation is unknown. It is not known if Motegrity is safe and effective in children.

Please click here for full Prescribing Information and Patient Information.