Actor Portrayal

Made to move your colon muscle

Motegrity is the only prescription medicine of its kind for adults with Chronic Idiopathic Constipation (CIC). Scroll to learn more about how it moves your colon muscle.

Chronic means having symptoms for at least 6 months. Idiopathic means the cause of the constipation is unknown.

Moves by Motegrity

When you think Motegrity, think colon muscle movement

Unlike other prescription medications for Chronic Idiopathic Constipation (CIC), Motegrity works differently by enhancing natural movements of the colon muscle, known as peristalsis.

Select Important Safety Information

Do not take Motegrity if you:

  • are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
  • have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn's disease, ulcerative colitis.

Here's how Motegrity works in 3 steps:

Ready. Set. Move.

Number 1
Ready

Taking Motegrity releases the active ingredient

It's absorbed and gets to work

Set

It targets a specific
receptor* in your colon

This enhances natural movements of the colon muscle

*Receptors are molecules that help cells communicate and bring about responses, such as colon muscle movements.

Number 2
Number 3
Move

Rhythmic muscle movements in your colon are increased

This helps your bowels move

You should know!

Motegrity is a “prokinetic” medicine
because it promotes colonic movement

Select Important Safety Information

Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:

  • have or have had depression, suicidal thoughts or actions, or mood problems
  • have kidney problems. Your HCP may give you a lower dose
  • are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby
  • are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Why My Colon Muscle?

Colon muscle movement

CIC and the moves behind bowel movements

As you can imagine, the muscle in our colon plays an important role in healthy bowel movements. So what about CIC? While the exact cause isn't known, it's thought that CIC may be caused by insufficient movement of the colon muscle.

Is Motegrity right for me?

About
Chronic Idiopathic Constipation

Gender

Women are more at-risk than men

Age

The risk of CIC increases as we age

Diet

Low-calorie diets may increase risk

CIC symptoms and possible risk factors

Chronic Idiopathic Constipation, or CIC for short, is a chronic bowel condition affecting as many as 35 million adults in the United States.* Chronic means having symptoms for at least 6 months. The term “idiopathic” simply means that the specific cause isn't known.

If you have CIC, you probably know the symptoms all too well. People entering Motegrity studies were living with infrequent and incomplete bowel movements, and may have experienced straining and hard stools.

Sound familiar?

You shouldn't have to manage symptoms of CIC alone. Be open when discussing them with your doctor and find out if Motegrity can help. And remember — just because CIC is “idiopathic”, it doesn't mean that effective treatments aren't available.

*Treatment may not be appropriate for everyone who has CIC.

WHAT IS MOTEGRITY?

Motegrity is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). Idiopathic means the cause of the constipation is unknown. It is not known if Motegrity is safe and effective in children.

Important Safety Information

Do not take Motegrity if you:

  • are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
  • have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease, ulcerative colitis.

Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:

  • have or have had depression, suicidal thoughts or actions, or mood problems
  • have kidney problems. Your HCP may give you a lower dose
  • are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby
  • are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Motegrity?
Motegrity may cause serious side effects, including:

  • unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your HCP immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or have tried to hurt yourself.
The most common side effects of Motegrity include:
  • headache
  • stomach area (abdominal) pain or bloating
  • nausea
  • diarrhea
  • dizziness
  • vomiting
  • gas
  • fatigue

These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. 
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for full Prescribing Information and Patient Information.

[{"pageName":"index","parentPage":"index","pageURL":"/","pageView":"Index","pageSubview":"","pageSubviewOrder":0,"navOrder":1,"menuLabel":"Home","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"Motegrity™ (prucalopride) | Patients","pageDescription":"Do not take if allergic to Motegrity, or have specific bowel problems. See PI. Motegrity, the only treatment of its kind for adults with Chronic Idiopathic Constipation. See the three steps that outline how it works.","pageFloodLightURL":""},{"pageName":"AlreadyTakingMotegrity","parentPage":"AlreadyTakingMotegrity","pageURL":"/already-taking-motegrity","pageView":"AlreadyTakingMotegrity","pageSubview":"","pageSubviewOrder":0,"navOrder":0,"menuLabel":"","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"Thank you for letting us know!","pageDescription":"","pageFloodLightURL":""},{"pageName":"HowItWorks","parentPage":"","pageURL":"/how-it-works","pageView":"1.0.HowItWorks","pageSubview":"","pageSubviewOrder":0,"navOrder":2,"menuLabel":"How It Works","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"How Motegrity™ (prucalopride) Works","pageDescription":"Learn more about Motegrity and find out how it works. Do not take if allergic to Motegrity, or have specific bowel problems. See PI.","pageFloodLightURL":""},{"pageName":"MotegrityMoves","parentPage":"","pageURL":"/how-it-works/increase-colon-muscle-movement","pageView":"1.0.HowItWorks","pageSubview":"1.1.MotegrityMoves","pageSubviewOrder":1,"navOrder":0,"menuLabel":"Moves by Motegrity","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"Increase Colon Muscle Movement in 3 steps","pageDescription":"Find out about a product that can increase colon muscle movements. Do not take if allergic to Motegrity, or have specific bowel problems. See PI. See the three steps that outline how it works.","pageFloodLightURL":""},{"pageName":"WhyColonMuscle","parentPage":"","pageURL":"/how-it-works/colon-movement-bowel","pageView":"1.0.HowItWorks","pageSubview":"1.2.WhyColonMuscle","pageSubviewOrder":2,"navOrder":0,"menuLabel":"Why My Colon Muscle?","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"Colon Movement and the Bowel","pageDescription":"Chronic Idiopathic Constipation (CIC) can impact the colon's role in healthy bowel movements. Find out the role that colon muscle movements play in the bowel. Do not take if allergic to Motegrity, or have specific bowel problems. See PI.","pageFloodLightURL":""},{"pageName":"AboutCIC","parentPage":"","pageURL":"/how-it-works/about-cic","pageView":"1.0.HowItWorks","pageSubview":"1.3.AboutCIC","pageSubviewOrder":3,"navOrder":0,"menuLabel":"About CIC","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"About Chronic Idiopathic Constipation (CIC)","pageDescription":"Chronic Idiopathic Constipation (CIC) is a chronic bowel condition affecting as many as 35 million adults in the US. See symptoms and risk factors. Do not take if allergic to Motegrity, or have specific bowel problems. See PI.","pageFloodLightURL":""},{"pageName":"WhatToExpect","parentPage":"","pageURL":"/what-to-expect","pageView":"2.0.WhatToExpect","pageSubview":"","pageSubviewOrder":0,"navOrder":3,"menuLabel":"What to Expect","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"What to Expect with Motegrity™ (prucalopride)","pageDescription":"Find out what to expect from Motegrity by viewing information about side effects and dosing. Do not take if allergic to Motegrity, or have specific bowel problems. See PI.","pageFloodLightURL":""},{"pageName":"SymptomImprovement","parentPage":"","pageURL":"/what-to-expect/cic-relief","pageView":"2.0.WhatToExpect","pageSubview":"2.1.SymptomImprovement","pageSubviewOrder":1,"navOrder":0,"menuLabel":"CIC Relief","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"Relief of Chronic Idiopathic Constipation (CIC)","pageDescription":"Do not take if allergic to Motegrity, or have specific bowel problems. See PI. Efficacy was studied in six clinical trials with 2,484 people living with Chronic Idiopathic Constipation (CIC). Learn more about their experiences during the trials.","pageFloodLightURL":""},{"pageName":"SideEffects","parentPage":"","pageURL":"/what-to-expect/side-effects","pageView":"2.0.WhatToExpect","pageSubview":"2.2.SideEffects","pageSubviewOrder":2,"navOrder":0,"menuLabel":"Possible Side Effects","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"Common Side Effects of Motegrity™ (prucalopride)","pageDescription":"Motegrity's safety profile was studied in over 1,200 adults. View most common side effects. Do not take if allergic to Motegrity, or have specific bowel problems. See PI.","pageFloodLightURL":""},{"pageName":"DailyDosing","parentPage":"","pageURL":"/what-to-expect/daily-dosing","pageView":"2.0.WhatToExpect","pageSubview":"2.3.DailyDosing","pageSubviewOrder":3,"navOrder":0,"menuLabel":"Once-Daily Dosing","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"How to Take Motegrity™ (prucalopride)","pageDescription":"View information related to the storage and dosing of Motegrity. Consult your doctor for specific usage instructions. Do not take if allergic to Motegrity, or have specific bowel problems. See PI.","pageFloodLightURL":""},{"pageName":"GettingStarted","parentPage":"","pageURL":"/getting-started","pageView":"3.0.GettingStarted","pageSubview":"","pageSubviewOrder":0,"navOrder":4,"menuLabel":"Getting Started","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"Getting Started with Motegrity™ (prucalopride)","pageDescription":"If you're interested in getting started with Motegrity, follow these steps and talk to your doctor. Do not take if allergic to Motegrity, or have specific bowel problems. See PI.","pageFloodLightURL":""},{"pageName":"ReadyToGo","parentPage":"","pageURL":"/getting-started/appointment-preparation","pageView":"3.0.GettingStarted","pageSubview":"3.1.ReadyToGo","pageSubviewOrder":1,"navOrder":0,"menuLabel":"Ready To Go","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"Talking to Your Doctor about Motegrity™ (prucalopride)","pageDescription":"See five important steps that you can follow when asking your doctor about Motegrity. Do not take if allergic to Motegrity, or have specific bowel problems. See PI.","pageFloodLightURL":""},{"pageName":"FAQ","parentPage":"","pageURL":"/getting-started/frequently-asked-questions","pageView":"3.0.GettingStarted","pageSubview":"3.2.FAQ","pageSubviewOrder":1,"navOrder":0,"menuLabel":"FAQ","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"Frequently Asked Questions about Motegrity™ (prucalopride)","pageDescription":"Do not take if allergic to Motegrity, or have specific bowel problems. See PI. From savings and support to study results and how it works, see the most frequently asked questions about Motegrity.","pageFloodLightURL":""},{"pageName":"SavingsSupport","parentPage":"","pageURL":"/savings-support","pageView":"4.0.SavingsSupport","pageSubview":"","pageSubviewOrder":0,"navOrder":5,"menuLabel":"Savings Support","pageController":"StaticPage","pageAction":"StaticPage","pageTitle":"Savings & Support for Motegrity™ (prucalopride)","pageDescription":"Contact Motegrity Answers by phone with questions about your coverage to save on your prescription fills. Do not take if allergic to Motegrity, or have specific bowel problems. See PI.","pageFloodLightURL":""},{"pageName":"savingsCard","parentPage":"savingsCard","pageURL":"/savings-card","pageView":"SavingsCard","pageSubview":"","pageSubviewOrder":0,"navOrder":6,"menuLabel":"Get Savings","pageController":"StaticPage","pageAction":"SavingsCard","pageTitle":"Savings Card for Motegrity™ (prucalopride)","pageDescription":"Sign up and activate your Motegrity Savings Card for a chance to save on your prescription fills. Do not take if allergic to Motegrity, or have specific bowel problems. See PI.","pageFloodLightURL":""},{"pageName":"savingsCardThankyou","parentPage":"savingsCard","pageURL":"/savings-card-thank-you","pageView":"SavingsCard","pageSubview":"","pageSubviewOrder":0,"navOrder":0,"menuLabel":"","pageController":"StaticPage","pageAction":"SavingsCard","pageTitle":"Savings Card for Motegrity™ (prucalopride)","pageDescription":"Sign up and activate your Motegrity Savings Card for a chance to save on your prescription fills. Do not take if allergic to Motegrity, or have specific bowel problems. See PI.","pageFloodLightURL":""},{"pageName":"Unsubscribe","parentPage":"","pageURL":"/unsubscribe","pageView":"Unsubscribe","pageSubview":"","pageSubviewOrder":0,"navOrder":0,"menuLabel":"","pageController":"StaticPage","pageAction":"Unsubscribe","pageTitle":"Unsubscribe | Motegrity™ (prucalopride)","pageDescription":"Please complete this form to unsubscribe from future Motegrity communications. Do not take if allergic to Motegrity, or have specific bowel problems. See PI.","pageFloodLightURL":""},{"pageName":"UnsubscribeRefillReminders","parentPage":"","pageURL":"/unsubscribe-refill-reminders","pageView":"UnsubscribeRefillReminders","pageSubview":"","pageSubviewOrder":0,"navOrder":0,"menuLabel":"","pageController":"StaticPage","pageAction":"UnsubscribeRefillReminders","pageTitle":"You have successfully unsubscribed from refill reminders!","pageDescription":"","pageFloodLightURL":""},{"pageName":"error","parentPage":"","pageURL":"/errors","pageView":"Error","pageSubview":"","pageSubviewOrder":0,"navOrder":0,"menuLabel":"","pageController":"StaticPage","pageAction":"Http404","pageTitle":"Sorry, this page is unavailable | Motegrity™ (prucalopride)","pageDescription":"","pageFloodLightURL":""}]